What is Prometrium (Progesterone) used for?

Prometrium (Progesterone) is a type of female hormone called progestin. It is similar to the progesterone that your body naturally makes and is given to replace the hormone when your body is not making enough of it. Prometrium is used to restore normal menstrual periods that have stopped for several months (amenorrhea).

Prometrium is also used as part of combination hormone replacement therapy with estrogens to reduce menopause symptoms such as hot flashes. Progesterone is added to estrogen replacement therapy to reduce the risk of cancer of the uterus.

How should I use Prometrium (Progesterone)?

Prometrium is not for use in children.

Prevention of Endometrial Hyperplasia:
Prometrium capsules should be given as a single daily dose at bedtime, 200mg orally for 12 days sequentially per 28-day cycle, to postmenopausal women with a uterus who are receiving daily conjugated estrogens tablets.

Treatment of Secondary Amenorrhea:
Prometrium capsules may be given as a single daily dose of 400mg at bedtime for 10 days.

Some women may experience difficulty swallowing Prometrium capsules. For these women, Prometrium capsules should be taken with a glass of water while in the standing position.

What are the side effects of Prometrium (Progesterone)?

• headache
• breast tenderness
• joint pain
• depression
• dizziness
• abdominal bloating
• hot flashes
• urinary problems
• abdominal pain
• vaginal discharge
• nausea
• vomiting
• chest pain
• diarrhea
• night sweats
• breast pain
• swelling of hands and feet
• vaginal dryness
• constipation
• breast carcinoma
• breast excisional biopsy
• cholecystectomy

Please Note

Before taking Prometrium, tell your physician or pharmacist if you are allergic to progesterone.

Prometrium should not be used if you have certain medical conditions. Always consult your physician or pharmacist if you have history of blood clots, history of bleeding in the brain, liver or kidney disease, cancer of the breast or other female organs, vaginal bleeding of unknown cause, a loss of pregnancy with some tissue remaining in the uterus, recent stroke or heart attack.

Prometrium may be used during pregnancy only as directed by your physician. This medicine passes into breast milk. Consult your physician before breast-feeding.