What is Estrofem (Oestradiol) used for?

Estrofem (Oestradiol) may be used as a supplement to, or substitution for, the ovaries' endogenous oestrogen production. Estrofem causes a decrease in or complete disappearance of oestrogen deficiency symptoms.

How should I use Estrofem (Oestradiol)?

Estrofem (Oestradiol) is taken by mouth either every day or on a cyclical basis: once a day for 21 days and then none for 7 days; then the cycle is repeated. However, for treating cancer it usually is taken three times a day, every day for at least 3 months.

What are the side effects of Estrofem (Oestradiol)?

• breast tenderness
• nausea
• headache
• oedema
• skin reactions

Please Note

Estrofem (Oestradiol) should not be prescribed for longer than one year without another physical examination including gynaecological examination being performed. If abnormal or irregular bleeding occurs during or shortly after therapy diagnostic aspiration biopsy or curettage should be performed to rule out the possibility of uterine malignancy. As a general rule for hormone replacement therapy (HRT) the lowest dose which alleviates the symptoms should be prescribed and medication should be discontinued as soon as possible.In patients treated with antihypertensive drugs and hormone replacement therapy (HRT) blood pressure should be monitored regularly.

Patients with epilepsy, migraine, diabetes, asthma or cardiac failure should be carefully controlled as oestrogens may worsen these conditions. Thromboembolism has been reported in connection with oestrogen replacement therapy but there is no background to believe that the overall incidence is increased.The indications for immediate withdrawal of therapy are: Deep venous thrombosis, thromboembolic disorders, the emergence of migraine-type headaches, sudden visual disturbances, significant increase in blood pressure. It is also advisable to withdraw treatment 4 to 6 weeks before major surgery. Estrofem has no contraceptive effects.