How does DBL Papaverine Hydrochloride Injection (Papaverine HCL) work:

DBL Papaverine Hydrochloride Injection is indicated for the treatment of erectile dysfunction.

Papaverine hydrochloride is the hydrochloride of an alkaloid obtained from opium or prepared synthetically. It belongs to the benzylisoquinoline group of alkaloids. The principal therapeutic action of papaverine is its relaxant effect on smooth muscles, which leads to penile erection. It may induce erections by arteriolar relaxation, increased blood flow and volume due to relaxation of the sinusoidal wall of the corpora cavernosa and subsequent compression of venous channels between the sinusoids and the tunica albuginea.

Dosage & Administration:

DBL Papaverine Hydrochloride Injection should only be prescribed, and treatment should be supervised.

A starting dose of 15mg is recommended for patients with erectile dysfunction due to most causes. Patients with psychogenic erectile dysfunction are likely to respond to lower doses, while those with vasculogenic erectile dysfunction are likely to require higher doses. Patients who do not respond to a dose of 60mg should be changed to alternative therapy.

A starting dose of 5mg is recommended for men with erectile dysfunction due to spinal cord injury.

Erection usually occurs within 10 minutes of injection of the drug and may persist for 1 to several hours. The dose should be reduced if erections persist for longer than 4 hours. Dosage adjustment should be made carefully, based on the degree and duration of tumescence achieved with the previous dose.

Side Effects:

• prolonged erection
• penile fibrosis
• injection site bruising / haematoma
• injection site blister / ulcer
• penile / foreskin oedema
• loss of penile sensation
• pain during erection
• infection / cavernositis / pyogenic granuloma
• thrombophlebitis
• intracorporal needle breakage
• fixed drug eruption
• penile fracture
• liver function abnormalities
• headache
• flushing
• a sensation of heat in the pelvis
• dizziness
• photopsia
• tachycardia
• hypotension
• syncope
• vasovagal reactions
• cardiac events
• allergic reactions
• urticaria
• impaired ejaculation
• death

Precautions:

See `Warning and Precautions` of Data Sheet.