Sandrena Gel (Estradiol/ Estradiol hemihydrates) is used as a hormone replacement therapy (HRT) to relieve distressful symptoms of the menopause. Sandrena Gel is available in 28 Sachets each 1mg.

Dosage & Administration Information:

Sandrena gel, to be used on the skin, can be used periodically or permanently. The common dose is 1.0mg estradiol (1.0g gel) daily. Whereas the initial dosage is changeable. The acuteness of the patient's symptoms are essential here. Depending on the doctor’s prescription, the dosage can be replaced after 2-3 cycles from 0.5g to 1.5g per day. Sandrena gel is best applied on the skin of the thighs. The gel evaporates in this way and the oestradiol is quickly absorbed through the skin into the blood circulation. The size of the treated part should be 1-2 time the size of a hand. Do not use Sandrena on the breasts, on the face or irritated skin. After usage the gel is supposed to dry for a couple of minutes. Do not wash the medicated part within 1 hour. Further, any contact of the gel with the eyes must be avoided. Wash hands after each application.

How does Sandrena Gel works:

Sandrena is used to replace the body's natural sex hormone oestrogen which is reduced after the menopause. Sandrena gel contains the active ingredient estradiol hemihydrates, which is a naturally occurring form of the main female sex hormone. Declining levels of oestrogen can cause symptoms like irregular periods, mood swings, night sweats, hot flushes, vaginal dryness and/ or itching.

Estradiol hemihydrates is generally used to avoid the falling levels of oestrogen in the body and help reduce stressfull symptoms of the menopause. This method is usually found under the name Hormone replacement therapy (HRT). HRT is commonly used for short-term relief from menopausal symptoms. Any longer-term treatments usually have to be discussed with your doctor.

Side Effects:

As specified below there are certain side effects incorporated with Estradiol hemihydrat. But only because these adverse reactions do occur from time to time, it is no allusion, that every person using this medicine will observe the below mentioned or any other side effects.

• Dizziness
• Gall bladder disease
• Skin reactions like itchy rash
• Breast pain, tenderness or enlargement
• Headache/migraine
• Changes in sex drive
• Depression
• Anxiety
• Vaginal rash

Precautions:

Before you start the treatment with Sandrena it is important and useful to discuss with your doctor any other medications you are already apply.

The following listed drugs may reduce the blood levels and the impact of Sandrena, which could have the result of recurrence of symptoms or irregular bleeding:

• Rifamycin antibiotics such as rifabutin and rifampicin
• Antipileptic medicines like carbamazepine, phenytoin, phenobarbital and primidone
• Protease inhibitors for HIV infection like ritonavir and nelfinavir
• Barbiturates like amobarbital

In addition, Sandrena should be used extremely cautious when:

• History of breast cancer
• History of benign breast lumps
• History of epilepsia
• History of asthma
• History of migraines
• History of diabetes

Further Advice:

Pregnancy and Lactation

Sandrena shall not be used during pregnancy. If the patient should get pregnant during usage with Sandrena, the treatment has to be stopped immediately. Sandrena is not advisable during lactation period.

Further Information:

Next to the 28 sachets (1mg/ 1g) the packaging comes with a practical little plastic box, providing space for seven Sandrena sachets for your weekly use.