How does Amaryl M (Glimepiride/Metformin HCL) work:

Amaryl M (Glimepiride/Metformin HCL) is the fixed dose combination of Glimepiride (Amaryl) and Metformin. It is indicated as an adjunct to diet and exercise in treatment of type 2 diabetes mellitus patients when they are not adequately controlled on either glimepiride alone or metformin alone or in replacement of the free combination of glimepiride and metformin.

Amaryl M offers the efficacy of glimepiride and metformin in just one pill BID which is favourable to a better compliance of treatment to achieve a better glycemic control. Amaryl M works by stimulating the pancreas to produce more insulin. Amaryl is often prescribed along with the insulin-boosting drug Glucophage. Amaryl M is also used in conjunction with insulin and other diabetes drugs.

Dosage & Administration:

Take Amaryl M (Glimepiride/Metformin HCL) strictly as directed by your physician. Amaryl should be taken with breakfast. The usual starting dose is 1 to 2 mg taken once daily. If you do not understand the correct dosage for your condition, you may need to consult your physician.

Safety and effectiveness in children have not been established.

Side Effects:

• anemia
• blurred vision
• diarrhea
• dizziness
• headache
• itching
• liver problems
• jaundice
• muscle weakness
• nausea
• sensitivity to light
• skin rash
• eruptions
• intestinal pain
• vomiting
• oma
• disorientation
• pale skin
• seizures
• shallow breathing

Precautions:

Avoid taking Amaryl M (Glimepiride/Metformin HCL) if you have ever had an allergic reaction to it.

Amaryl M may lead to more heart problems than diet treatment alone, or treatment with diet and insulin. If you have a heart condition, you should discuss this with your physician. When taking Amaryl M, you should check your blood and urine regularly for abnormally high glucose levels. Even people with well-controlled diabetes may find that stress such as injury, infection, surgery or fever triggers a loss of control. If this happens, your physician may recommend that you add insulin to your treatment with Amaryl M or that you temporarily stop taking Amaryl M and use insulin instead. Possible food and drug interactions when taking Amaryl M.

Do not take Amaryl M while pregnant. Since studies suggest the importance of maintaining normal blood sugar levels during pregnancy, your physician may prescribe injected insulin instead. Drugs similar to Amaryl M do appear in breast milk and may cause low blood sugar in nursing infants. You should not take Amaryl M while nursing. If diet alone does not control your sugar levels, your physician may prescribe injected insulin.