How does Apo-Moclobemide (Moclobemide) work:

Apo-Moclobemide is an antidepressant drug of the reversible inhibitor of Monamine Oxidase Inhibitors. It is used to treat depression, panic and social phobia. Apo-Moclobemide is commonly used when other antidepressants have failed to have an effect.

When depression occurs, there may be a decrease in the amount of certain chemicals released from nerve cells in the brain. These chemicals are called monoamines and include noradrenaline, dopamine and serotonin. Monoamines in the brain are broken down by a chemical called monoamine oxidase A. Moclobemide prevents the action of this chemical, and so stops it from breaking down the monoamines. This results in an increased amount of active monoamines in the brain. By increasing the amount of monoamines in the brain, the imbalance of chemicals thought to cause depression is altered. This helps relieve depression.

Dosage & Administration:

The recommended dose range is 300 - 600 mg daily usually administered in two to three divided doses after a meal. The initial dose is 300 mg daily.

Side Effects:

• Sleep disturbances including insomnia
• Dizziness
• headache
• confusion
• agitation
• anxiety
• irritability
• restlessness
• paraesthesia
• dry mouth
• visual disturbances
• gastro-intestinal complaints (such as nausea, vomiting, constipation, diarrhoea, loss of appetite)
• skin reactions (such as rash, pruritus, urticaria and flushing)
• and hypotension

Further Information:

It may take between two to four weeks for the benefits of this medicine to appear, so it is very important that you keep taking it, even if it doesn't seem to make much difference at first. If you feel your depression has got worse, or if you have any distressing thoughts or feelings in these first few weeks, then you should talk to your physician.